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When you vape CBD , it enters your lungs and takes effect quickly, and also leaves the body quickly. Oils and tinctures placed under your tongue are absorbed into the bloodstream faster and linger longer. The frequency of your usage also determines how long CBD stays in your body. This is why it’s recommended you use it for at least a week to see if it works for you. Though it's often well-tolerated, CBD can cause side effects, such as dry mouth, diarrhea, reduced appetite, drowsiness and fatigue.